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Our Principal Areas of Expertise

Main R&D Areas

Synthetic Chemistry​

  • Design and synthesis of novel lipids and lipidoids

  • Design and synthesis of novel polymers

  • Radiolabeled and stable-isotope lipids to support ADME studies

  • Synthetic process technology transfer to Contract Research Organization (CRO)

Product Formulation And Scale-up

  • Formulation development and optimization using scalable components and processes

  • Process characterization and optimization

  • Manufacturing process technical transfer to CRO

Analytical And Biophysical Characterization

  • Analytical methods development and transfer, including lipid and nucleic acid-specific analyses

  • Biophysical characterization including LNP size and size distribution encapsulation, surface charge and pKa, cryo-electron microscopy

  • Bioanalytical method development and analyses for LNP components

Preclinical characterization

Pharmacodynamic studies for protein replacement therapeutics

  • Reporter gene (e.g. luciferase) expression in vivo by luminescent live-imaging

  • Reporter tissue/cell gene expression ex vivo by flow cytometry,luminescence spectroscopy

  • Transgene expression by immunohistochemistry/immunocytochemistry

Safety/tolerability studies

  • Clinical pathology/histopathology

  • Immune response characterization (e.g. complement,

  • cytokines/chemokines)

Bioanalytical

  • Nucleic acid therapeutic

  • LNP components

Research Program Management

We focus on successful management of the research program to meet partner objectives:

  • Coordination and execution of Partner Work Plan

  • Monitoring budget, resources and timelines

  • Regular communication with partner program management team to ensure alignment

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